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The Hypothalamic-Pituitary-Adrenal Axis in Health and Disease : Cushing's Syndrome and Beyond

Cushing´s syndrome is a rare disorder that is associated with many co-morbidities such as systemic hypertension, diabetes, osteoporosis, impaired immune function, and psychiatric disease, all of which severely reduce quality of life and life expectancy. This book reviews the role of cortisol in the... Celý popis

Instituce: Tomas Bata University
Korporativní autor: SpringerLink (Online service)
Další autoři: Geer, Eliza B.
Médium: E-kniha
Jazyk: English
Vydáno: Cham : Springer International Publishing : 2017
Témata:
Medicine.
Endocrinology.
Systems biology.
elektronické knihy
electronic books
On-line přístup: https://proxy.k.utb.cz/login?url=http://dx.doi.org/10.1007/978-3-319-45950-9
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Obsah:
  • Part 1. Hypothalamic-pituitary-adrenal axis regulation of the body, brain, and inflammation
  • 1. Glucocorticoid regulation of body composition and metabolism
  • 2. Glucocorticoid regulation of neurocognitive and neuropsychiatric function
  • 3. Glucocorticoids: Inflammation and Immunity
  • Part 2. Cushing's Syndrome
  • 4. Pathogenesis, diagnosis and localization of Cushing's: Molecular pathogenesis of primary adrenal Cushing's syndrome
  • . 5. Pathogenesis, diagnosis and localization of Cushing's
  • 5. Pathogenesis, diagnosis and localization of Cushing's: Pathogenesis and treatment of aggressive corticotroph pituitary tumors - Yang Shen and Anthony P Heaney
  • 6. Pathogenesis, diagnosis and localization of Cushing's: Neoplastic/Pathologic and Non-neoplastic/Physiologic Hypercortisolism: Cushing verses Pseudo-Cushing Syndromes
  • 7. Pathogenesis, diagnosis and localization of Cushing's: Imaging strategies for localization of ACTH - secreting tumors
  • 8. Recent Advances in the medical and surgical treatment of Cushing's: Surgical Treatment of Cushing's disease
  • 9. Recent Advances in the medical and surgical treatment of Cushing's: Medical therapies in Cushing's syndrome
  • 10. New themes in Cushing's definitions and outcomes: Mild adrenal cortisol excess - 11. New themes in Cushing's definitions and outcomes: Long term effects of prior Cushing's syndrome
  • 12. New themes in Cushing's definitions and outcomes: Cushing's disease: refining the definition of remission and recurrence
  • Part 3. Beyond Cushing's: Glucocorticoid sensitivity, regulation and the metabolic syndrome
  • 13. Primary Generalized Glucocorticoid Resistance or Chrousos Syndrome: Allostasis through a Mutated Glucocorticoid Receptor
  • 14. Cortisol metabolism as a regulator of the tissue-specific glucocorticoid action
  • 15. Obesity and metabolic syndrome: a phenotype of mild long-term hypercortisolism.

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